Twisting, untwisting and diastolic function in aortic valve disease

Twisting, untwisting and diastolic function in aortic valve disease.

Global and regional deformation of left ventricular muscle tissue is sensitive to a variety of cardiac disorders such as coronary artery disease and pressure–load hypertrophy. In the domain of coronary artery disease, changes in local wall motion and thickening may occur in acute and chronic myocardial infarction, and during stress-induced myocardial ischaemia. Under conditions of pressure over...

Pulsus alternans: its influence on systolic and diastolic function in aortic valve disease.

Left ventricular high fidelity pressure measurements and simultaneous biplane cineangiocardiography were performed in 12 patients with severe aortic valve disease (aortic stenosis in 10, aortic insufficiency in 1 and combined valve lesion in 1). Left ventricular contractility was estimated from maximal rate of left ventricular pressure rise (max dP/dt), peak measured velocity of contractile ele...

Vascular Function in Bicuspid Aortic Valve Disease

Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement.

Passive diastolic properties were determined in 10 control patients and 21 patients with aortic valve disease before and 17.5 months after successful valve replacement. Ten patients had severe aortic stenoses (AS), five had combined aortic valve lesions (AS + aortic insufficiency [AI]), and six patients had severe AI. Left ventricular endomyocardial biopsies were obtained before and after surge...

Altered diastolic function and aortic stiffness in Alzheimer’s disease

BACKGROUND Alzheimer's disease (AD) is closely linked to cardiovascular risk factors. METHODS Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with ...